Marc Minkowski began conducting at an early age. In 1982, he founded Les Musiciens du Louvre, exploring French Baroque music and Handel, before expanding their repertoire to Mozart, Rossini, Offenbach, Bizet, and Wagner. He regularly conducts in Paris (Opéra National, Théâtre du Châtelet and Opéra Comique), at Covent Garden and La Scala, at the Salzburg and Aix-en-Provence Festivals, in Brussels, Zurich, Venice, Moscow, Berlin, Amsterdam, Vienna (Theater and der Wien and Staatsoper). In 2015, he initiated a relationship with the Drottningholm Festival in Sweden centered  around the Mozart/Da Ponte trilogy, in collaboration with the Opéra Royal of the Château de Versailles. Marc Minkowski is also in high demand on the concert platform conducting orchestras such as BBC Symphony Orchestra, Tokyo Metropolitan Symphony Orchestra, DSO Berlin, Vienna Philharmonic, Salzburg Mozarteum Orchestra, Mahler Chamber Orchestra, Swedish Radio Orchestra...

The highlights of his 2018/2019 operatic season as a conductor include : Pelléas et Mélisande in Japan, der Freischütz in Berlin Staatsoper Unter den Linden, Il Barbiere di Siviglia at the Opéra National de Bordeaux, Manon both in Bordeaux and at the Opera Comique in Paris. Appointed General Manager of the Opéra National de Bordeaux in 2016, he founded the Ré Majeure Festival in 201, was the Artistic Director of the Mozartwoche Salzburg from 2013 to 2017, and becomes the Artistic Advisor of Kanazawa Orchestra (Japan) from September 2018.